Diagnostic Analysis and Reporting Tool

DART can be deployed both as a web server installation and as a standalone tool running locally on your machine:

Try out a demo dataset or Install standalone DART

Finding the one in a million

Rare und undiagnosed diseases are often caused by genetic defects. Rapid identification of the causal mutation(s) provides a molecular diagnosis that can inform potentially invasive treatment decisions and reduces the need for lengthy (and often costly) testing. Genetic diagnoses are currently hampered by the large number of potential disease genes, by the high number of variants identified and by the complexity of variant annotation, which can lead to major delays in reaching a confident genetic diagnosis.

Reporting variants

DART is a user-friendly, non-commercial software tool that assists researchers and clinicians with the filtering and interpretation of genetic variants obtained by next generation sequencing (e.g. diagnostic panels, exome sequencing, or whole genome sequencing. DART facilitates confident genetic diagnoses in compliance with emerging community standards. Starting with an annotated VCF file, DART supports interactive filtering, implements ACMG-AMP classification, provides full audit history, and helps generate custom patient reports.

Going the extra mile

Starting with an annotated VCF file, DART supports the user by providing

• Sample focused analysis
• Virtual gene panels
• Standardized filtering
• Interactive exploration and visualization of variants
• Disease focused variant analysis
• Trio / relatedness variant representation
• Support ACMG-AMP variant curation

Full control

DART rivals commercial variant annotation software in terms of features and user-friendliness, and – as an open source software with no strings attached – it puts the full control over genetic data back in the hands of the clinical laboratories that analyse the data. It thus avoids undue commercialization of genome data and facilitate responsible sharing.